With an increasing focus on sustainable development and the reuse of disused infrastructure, there is a pressing need for effective decision-making methods.This study explored the use of the PROMETHEE method within a collaborative decision-making framework to assess the adaptive reuse options for a disused railway in Sicily, Italy.Using a participa
Intra-periaqueductal Grey Matter Injection of Orexin A Attenuates Nitroglycerin-induced Deficits in Learning and Memory in Male Rats
This study explored the potential contribution of Orx1R within vlPAG to the learning and memory of animals with chronic migraine-like pain.Migraine was induced by repeated i.p.administration of nitroglycerin (5 mg/kg).Passive avoidance adeptness was evaluated in the shuttle box maze.The spatial memory performance was estimated using MWM tests.In th
Molecular Mechanism of the Cell Death Induced by the Histone Deacetylase Pan Inhibitor LBH589 (Panobinostat) in Wilms Tumor Cells.
Wilms tumor (WT) is an embryonic kidney cancer, for which histone acetylation might be a therapeutic target.LBH589, a novel targeted agent, suppresses histone deacetylases in many tumors.This study investigated the antitumor activity of LBH589 in SK-NEP-1 and G401 cells.SK-NEP-1 and G401 cell growth was assessed by CCK-8 and in nude mice experiment